The 25 most profitable publicly-listed American companies that appear in the Forbes Global 2000 list for 2010 are listed below:

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The oil giant ExxonMobil(XOM) made the highest profits at over $19B on sales of $275B. The second and third spots were taken by software maker Microsoft(MSFT) and the world’s largest retailer Wal-Mart Stores(WMT). Among the banks in the top 100 companies, Citibank(C) is notably absent. Though PepsiCo(PEP) has higher sales than Coca Cola(KO) its profit margin is less. Seven tech firms are in the top 25 underscoring the strength and profitability of this sector.

The full list of the 100 most profitable U.S. companies can be found here.

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